The Allure of the “Magic Pill”

What Science Says About Dietary Supplements to Help Tinnitus

By Cláudia Barros Coelho, MD, PhD

Dietary supplements appeal to patients who want a “magic pill” for tinnitus. Playing into that desire is an abundance of advertisements on the internet, on television, and in magazines offering a quick fix for tinnitus. The pills are typically low-cost, over-the-counter drugs that are purported to have remarkable benefits, according to their manufacturers. The fact that they are often labeled “natural” plays into the notion that they are safe and effective, which isn’t always the case. 1, 2

What Exactly is a Dietary Supplement?

It’s a pill containing an ingredient intended to supplement the diet. Ingredients might include vitamins, minerals, herbs or other botanicals, amino acids, and substances such as enzymes. The National Institutes of Health estimates that approximately 40 percent of Americans – many tinnitus patients among them – take some form of dietary supplement.

In a recent online survey of 1,788 people with tinnitus from 53 countries, 23 percent of participants reported using dietary supplements, such as vitamins, herbs, minerals, homeopathic compounds, and Chinese phytotherapics, to treat tinnitus.3 Fifty-two substances were described, with the most common being Ginkgo biloba (26.6%), lipoflavonoid (12.9%), vitamin B12 (8.6%), zinc (8.6%), magnesium (6.6%), and melatonin (4.6%). Only 19.1 percent of all treatments were recommended by a physician. The internet was the source most frequently used for purchasing the supplements (40%).

The supplements were considered ineffective for tinnitus by 70.7 percent of subjects. Improvement in tinnitus was reported by 19.0 percent of patients, with 10.3 percent responding that a supplement had negative effects (worsened tinnitus). The survey results confirm the lack of efficacy of dietary supplements for tinnitus and correlate with findings of previous studies. 4

The U.S. Food and Drug Administration (FDA) has not approved any dietary supplements for tinnitus treatment, even though some studies have suggested benefit for a subgroup of tinnitus patients. 8 Perhaps a specific subgroup might benefit from taking dietary supplements, but, to date, only a limited number of well-designed investigations have tested the efficacy of dietary supplements for tinnitus.9, 10

The different results shown in available studies are probably attributable to differences in methodology, forms of presentation, dosage, and purity of the product. 11, 12

Despite the disparate findings, patients and physicians look to dietary supplements to ease symptoms of tinnitus and its associated distress.

What Research Says About Dietary Supplements and Tinnitus

Ginkgo biloba

Yellow ginkgo biloba leafGingko biloba in the form of EGB 761 (standard Ginkgo biloba leaf extract containing 24% of glycoside flavonoids and 6% of terpene lactones) is the most widely prescribed dietary supplement as a treatment for peripheral vascular disease (insufficient blood flow to the limbs because of damage to blood vessels) and cerebral insufficiency (not enough blood reaching the brain) that causes concentration difficulties, memory loss, dizziness, and tinnitus.
Ginkgo is also the most studied dietary supplement in tinnitus treatment. It is believed to improve tinnitus by increasing inner ear and cerebral blood circulation and by protecting against free radicals. Several clinical trials have been performed on tinnitus patients, but the results are conflicting, with some showing positive effects and others showing no effect.13, 14 People with seizures (as in epilepsy) or bleeding disorders should not use ginkgo.


Zinc is an element present in all organs, tissues, fluids, and secretions of the body and is essential for stabilizing the internal environment of the body. In the auditory pathway, zinc plays a critical role in several aspects of cochlear and neuronal function. Changes in zinc absorption or excretion or an increase in body requirements can result in zinc deficiency. This is particularly common among the elderly, vegetarians, and alcoholics. Clinical manifestations include diarrhea, hair loss, muscle wasting, depression, irritability, and a rash on the extremities, face, and perineum. Zinc deficiency has also been related to tinnitus.15
A few studies have evaluated zinc supplements for treating patients with tinnitus. Zinc was no more effective in the treatment of tinnitus than placebo in a group of elderly patients in a randomized double-blind placebo control study. However, a subgroup of subjects with zinc deficiency might have derived some benefit.16, 17

Zinc supplements are generally well tolerated, with the most common side effects limited to poor digestion, abdominal pain, and nausea.

Vitamin B12

Vitamin B12 is an essential vitamin for the body that affects neurologic and circulatory functions. Vitamin B12 deficiency might impair the vascular and nervous systems of the auditory system and has been implicated in hearing loss and tinnitus. Vitamin B12 deficiency is caused by dietary deficiencies or poor absorption. Because vitamin B12 cannot be synthesized by the body, a dietary source, such as fish, meat, poultry, eggs, and milk and other dairy products, is critical.
Preliminary testing of vitamin B12 to treat tinnitus suggests that it could improve tinnitus.18-20 Vitamin B12 supplements are usually well tolerated, with mild side effects including diarrhea, skin rashes, and headaches.


Melatonin is a hormone produced by the pineal gland and in different cells and tissues of the body, including the cochlea. Among its properties, it helps facilitate sleep, protects against damaging free radicals and ototoxic drugs, and has antioxidant effects. It has been used in the treatment of sleep disorders. A review of studies of melatonin in tinnitus treatment concluded that it could have a positive effect on sleep problems caused by tinnitus.21 Melatonin appears to be safe when used short term, but it is yet unknown whether extended use is safe. Side effects are uncommon but can include drowsiness, headache, dizziness, or nausea.


Flavonoids are a diverse group of phytonutrients (plant chemicals) found in almost all plant foods. Flavonoids represent a large class of at least 6,000 phenolic compounds that appear in fruits, vegetables, herbs, cocoa, chocolate, tea, soy, red wine, and other edible plants and beverages. Flavonoids exhibit protective effects on cardiovascular and neurologic functions and are credited with reducing inflammation and incidence of cancer.

Epidemiological studies suggest that lower consumption of flavonoid-rich diets is associated with the development of many age-related diseases, including cancer, cardiovascular disease, diabetes, osteoporosis, and neurodegenerative disorders.22
Lipoflavonoid, a compound of vitamins and flavonoids, is widely advertised on the internet and in magazines as a tinnitus treatment. Only one clinical trial has evaluated the use of Lipoflavonoid Plus® alone or in association with manganese. Neither supplement was shown to be effective in reducing tinnitus.23


Magnesium is an essential element that plays a key role in many body functions, including in the auditory pathway. Research studies show decreased serum magnesium levels to be associated with tinnitus, implicating magnesium in the pathophysiology of subjective tinnitus.24
Some preliminary study results demonstrated that magnesium supplements likely benefit ear functions and suggested it might have a beneficial effect on tinnitus perception.25, 26

No “Magic Pill”

The research is clear in showing that dietary supplements are ineffective for reducing the perception of tinnitus, which is why the American Academy of Otolaryngology–Head and Neck Surgery Foundation's Clinical Practice Guideline: Tinnitus states that clinicians should not recommend Ginkgo biloba, melatonin, zinc, or other dietary supplements for treating patients with persistent bothersome tinnitus.27 While it is understandable that people bothered by tinnitus would try supplements, thinking they might fall into that subcategory of patients who sometimes find relief, it’s important to consider the risks of adverse effects, as well as to acknowledge that the ingredients may not be safe. If you’re determined to try them despite that, then you should have blood work done to determine if you have vitamin and mineral defiencies, and discuss with your physician which supplements would be appropriate based on those results.

Cláudia Barros Coelho, MD, PhD, is an otolaryngologist who has specialized in the management of tinnitus and hyperacusis for over 20 years. She is a professor of otolaryngology at UNIVATES Medical School, Lajeado, Brazil, and an associated research scientist in the Otolaryngology and Head and Neck Surgery Department at the University of Iowa, Iowa City. She is an international speaker on tinnitus and hyperacusis. Her research on tinnitus and hyperacusis has been published extensively, and she has written many chapters in books on tinnitus.



1 Sax, J. K. (2015). Dietary supplements are not all safe and not all food: How the low cost of dietary supplements preys on the consumer. American Journal of Law and Medicine, 41(2/3), 374-394.
2 Coelho, C. (2016). Medications, supplements and alternative medicine. In R. S. Tyler (Ed.), The consumer handbook on tinnitus (pp. 211-226). Sedona, AZ: Auricle Ink Publishers.
3 Coelho, C., Tyler, R., Ji, H., Rojas-Roncancio, E., Witt, S., Tao, P., ... Gantz, B. J. (2016). Survey on the effectiveness of dietary supplements to treat tinnitus. American Journal of Audiology, 25(3), 184-205.
4 Ibid.
5 Ibid.
6 National Center for Complementary and Integrative Health. (2018). Dietary and herbal supplements. Retrieved from
7 Tyler, R. Haskell, G., Preece, J., & Bergan, C. (2001). Nurturing patient expectations to enhance the treatment of tinnitus. Seminars in Hearing, 22(1), 15-21.
8 Tunkel, D. E., Bauer, C. A., Sun, G. H., Rosenfeld, R. M., Chandrasekhar, S. S., Cunningham, E. R., Whamond, E. J. (2014). Clinical practice guideline: Tinnitus. Otolaryngology—Head and Neck Surgery, 151(2 Suppl.), S1-S40.
9 Tyler, R. Noble, W. G., & Coelho, C. (2006). Considerations for the design of clinical trials for tinnitus. Acta Oto-Laryngologica, 126(1), 44-49.
10 Tyler, R., Coelho, C., Tao, P., Ji, H., Noble, W., Gehringer, A., & Gogel, S. (2008). Identifying tinnitus subgroups with cluster analysis. American Journal of Audiology, 17(2), 176-184.
11 Tyler, R., Noble, W. G., & Coelho, C. (2006). Considerations for the design of clinical trials for tinnitus. Acta Oto-Laryngologica, 126(1), 44-49.
12 Coelho, C., Witt, S. A., Ji, H., Hansen, M. R., Gantz, B., & Tyler, R. (2013). Zinc to treat tinnitus in the elderly. Otology & Neurotology, 34(6), 1146-1154.
13 von Boetticher, A. (2011). Ginkgo biloba extract in the treatment of tinnitus: A systematic review. Neuropsychiatric Disease and Treatment, 7, 441-447.
14 Hilton, M., Zimmermann, E., & Hunt, W. (2013). Ginkgo biloba for tinnitus. Cochrane Database of Systematic Reviews, 28;(3):CD003852. doi:10.1002/14651858.CD003852.pub3
15 Coelho, C., Tyler, R., & Hansen, M. (2007). Zinc as a possible treatment for tinnitus. Progress in Brain Research, 166, 279-285.
16 Ibid.
17 Coelho et al., 2013.
18 Shemesh, Z., Attias, J., Ornan, M., Shapira, N., & Shahar, A. (1993). Vitamin B12 deficiency in patients with chronic-tinnitus and noise-induced hearing loss. American Journal of Otolaryngology, 14(2), 94-99.
19 Berkiten, G., Yildirim, G., Topaloglu, I., & Ugras, H. (2013). Vitamin B12 levels in patients with tinnitus and effectiveness of vitamin B12 treatment on hearing threshold and tinnitus. B-ENT, 9(2), 111-116.
20 Singh, C., Kawatra, R., Gupta, J., Awasthi, V., & Dungana, H. (2016). Therapeutic role of vitamin B12 in patients of chronic tinnitus: A pilot study. Noise & Health, 18(81), 93-97.
21 Miroddi, M., Bruno, R., Galletti, F., Calapai, F., Navarra, M., Gangemi, S., & Calapai, G. (2015). Clinical pharmacology of melatonin in the treatment of tinnitus: A review. European Journal of Clinical Pharmacology, 71(3), 263-270.
22 Panche, A. N., Diwan, A. D., & Chandra, S. R. (2016). Flavonoids: An overview. Journal of Nutritional Science, 5, e47.
23 Rojas-Roncancio, E., Tyler, R., Jun, H.-J., Wang, T.-C., Ji, H., Coelho, C., Gantz, B. (2016). Manganese and Lipoflavonoid Plus to treat tinnitus: A randomized controlled trial. Journal of the American Academy of Audiology. doi:10.3766/jaaa.15106
24 Uluyol, S., Kılıçaslan, S., Yagız, Ö. (2016). Relationship between serum magnesium level and subjective tinnitus. Kulak Burun Bogaz Ihtis Derg, 26(4), 225-227.
25 Attias, J., Reshef, I., Shemesh, Z., & Salomon, G. (2002). Support for the central theory of tinnitus generation: A military epidemiological study. International Journal of Audiology, 41(5), 301-307.
26 Uluyol et al., 2016.
27 Tunkel et al., 2014.